The authors present the essence of statistical reasoning in clinical trials,peppered with well-known clinical trials This book uses only a small number of important principles to develop the entire statistical foundation of clinical trials in approximately 200-250 pages. Therefore, readers will acquire a formidable statistical armamentarium in a fairly short time. It includes detailed case studies of trials such as the Extracorporeal Membrane Oxygenation trial, the Cardiac Arrhythmia Suppression Trial, and the Women’s Health Initiative.