Genesis Machine: Our Quest to Rewrite Life in the Age of Synthetic Biology

"Synthetic biology is the promising and controversial technology platform that combines biology and artificial intelligence, opening up the potential to program biological systems much as we program computers. Synthetic biology enables us not just to read and edit DNA - the technique of CRISPR - but also write it. Rather than life being "a beautiful game of chance", synthetic biology creates the potential to control our genetic destiny, to say "no" to bad genes and build a veritable genetic app store fordownloading and adding new capabilities into any cell, microbe, plant, or animal. Amy Webb and Andrew Hessel's riveting stories include: the work of scientists to develop plants that can be grown in sprawling indoor farms capable of feeding millions witha fraction of the usual resources required; a synthetic, self-regulating insulin that doesn't require injections or a pump; life-altering regenerative, personalized medicine; and novel, durable solutions to climate change. There is also whimsy, such as the dream of some geneticists to "unextinct" the wooly mammoth. By examining both the science and the ethical, moral, and religious issues surrounding synthetic biology, Webb and Hessel provide the background for preventing its misuse by some to re-engineer their bodies and that of their children, further increasing the disturbing division and polarization of societies into the haves (the enhanced) and the have nots. They provide the background for making wise decisions about issues such as: whether to program novel viruses to fight diseases, what genetic privacy will look like, who will "own" living organisms, how companies should earn revenue from engineered cells, and how to contain a synthetic organism in a lab. Whether we approve or disapprove of synthetic biology, it is coming. Now, we need to understand its promise and peril. Webb and Hessel help us understand the science as well as the political and societal issues involved"--
By examining both the science and the ethic, moral and religious issues surrounding synthetic biology, the authors discuss its potential for helping solve humanity’s existential challenges. 30,000 first printing.
The next frontier in technology is inside our own bodies.Synthetic biology will revolutionize how we define family, how we identify disease and treat aging, where we make our homes, and how we nourish ourselves. This fast-growing field—which uses computers to modify or rewrite genetic code—has created revolutionary, groundbreaking solutions such as the mRNA COVID vaccines, IVF, and lab-grown hamburger that tastes like the real thing.  It gives us options to deal with existential threats: climate change, food insecurity, and access to fuel.But there are significant risks.Who should decide how to engineer living organisms? Whether engineered organisms should be planted, farmed, and released into the wild? Should there be limits to human enhancements? What cyber-biological risks are looming? Could a future biological war, using engineered organisms, cause a mass extinction event? Amy Webb and Andrew Hessel’s riveting examination of synthetic biology and the bioeconomy provide the background for thinking through the upcoming risks and moral dilemmas posed by redesigning life, as well as the vast opportunities waiting for us on the horizon.